Animal Models of Non Cirrhotic Portal Hypertension (ncph)

Portal hypertension (PHT) is a common and serious clinical syndrome often associated with chronic liver diseases. Portal hypertension may be defined as portal pressure gradients of 12 mmHg or more in the veins of the portal system caused by obstruction in the liver from intrahepatic or extrahepatic portal venous compression or occlusion (often associated with chronic liver disease), causing enlargement of the spleen and collateral veins. In the western world, hepatic cirrhosis related to chronic hepatitis C and B and alcoholic cirrhosis are the conventional rationale for the development portal hypertension. Besides cirrhosis, a number of disorders collectively called as noncirrhotic portal hypertension (NCPH) can also result in portal hypertension. Evaluation of non-cirrhotic portal hypertension is more difficult than cirrhotic portal hypertension, both from clinical and pathological perspectives. صخلم : عافترا طغض وذنا ًتاثنا ىه حيزلاتي حٌرٌرس حؼئاش جرطخو اثناغو اي طثترت غي ضاريأ ذثكنا حنيسًنا . نكًٌو فٌرؼت عافترا طغض وذنا ًتاثنا ايذنػ مصٌ طغضنا ًف جدروا واظننا ًتاثنا ًنا 21 ىهي قثئز وأ رثكأ جتانناو نػ داذسنا وا طغضنا ًهػ جدرولاا حٍتاثنا مخاد ذثكنا ( ةحاصًناو جداػ ضاريلأ ذثكنا حنيسًنا ) ، اًي ةثسٌ ًف ىخضت لاحطنا جدرولأاو حٍثناجنا . ًف ىناؼنا ،ًترغنا غًشت ذثكنا مصتًنا باهتنات ذثكنا نيسًنا C و B فٍهتو ذثكنا جتاننا نػ لىحكنا ني باثسلاا حٌذٍهقتنا عافترلا طغض وذنا ًتاثنا . حفاضلإات ىنا فٍهت ،ذثكنا كنانه ارطضا خات يرخا ىًست حؼًتجي ىسات عافترا طغض وذنا مخذًنا رٍغنا طثتري فٍهتت ذثكنا يدؤٌ اضٌأ ىنإ عافترا طغض وذنا ًتاثنا . ىٍٍقت عافترا طغض وذنا ًتاثنا رٍغنا طثتري فٍهتت ذثكنا ىه رثكأ حتىؼص ني ىٍٍقت عافترا طغض وذنا ًتاثنا جتاننا ني فٍهتنا ،يذثكنا ني جو ح رظننا حٌرٌرسنا حٍضرًناو Received: 16 December, 2012; Accepted: 6 March, 2013 *Correspondence: [email protected] 1 Assistant Professor, Medical Physiology, College of Applied Medical Science Al-Majmaah University, Majma’ah, Kingdom of Saudi Arabia. REVIEW ARTICLE MAJMAAH J. HEALTH SCIENCES, 2013 – Vol. 1, No. 1 Non-Cirrhotic Portal Hypertension, Moattar R Rizvi 65 INTRODUCTION Non-cirrhotic portal fibrosis (NCPF) and extra-hepatic portal vein obstruction (EHPVO) are very common in developing countries and almost always present only with characteristic features of portal hypertension. Non-cirrhotic portal fibrosis (NCPF), the equivalent of idiopathic portal hypertension in Japan and hepatoportal sclerosis in the United States of America, is a common cause of portal hypertension in India and accounts for 15-40% (8,21,37) . Its etiopathogenesis is still obscure, as patients present late when bleeding has already occurred from the varices. The disease is common in the lower or lower– middle socio-economic strata of society. Improved hygienic standards of living could explain the relative rarity of the disease in the West and declining incidence in Japan. EXPERIMENTAL MODEL OF